ICD Code C91.10

ICD code C91.10 is chronic lymphocytic leukemia of B-cell type that has not achieved remission.

1. Presence of a persistent lymphocytosis with an absolute B-cell count ≥5,000/μL in peripheral blood.

2. Confirmation of B-cell clonality by flow cytometry or immunophenotyping.

3. Absence of symptoms or findings indicating remission, such as normalization of blood counts or resolution of lymphadenopathy, splenomegaly, or hepatomegaly.

4. No evidence of transformation to a more aggressive lymphoma (Richter’s transformation).

5. Absence of prior documentation of complete or partial remission.

6. May present with symptoms such as fatigue, night sweats, unexplained weight loss, or recurrent infections.

7. Laboratory findings may include anemia, thrombocytopenia, or hypogammaglobulinemia.

8. Lymphadenopathy and/or splenomegaly may be present on physical examination or imaging.

Applicable CPT codes for ICD code C91.10 may include:

- 36415 (Collection of venous blood by venipuncture)

- 85025 (Complete blood count, automated, and automated differential WBC count)

- 88184 (Flow cytometry, first marker)

- 88185 (Flow cytometry, each additional marker)

- 81261 (BCR/ABL1 gene analysis)

- 96365 (Intravenous infusion, for therapy, initial, up to 1 hour)

- 96413 (Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug)

- 96415 (Chemotherapy administration, intravenous infusion technique; each additional hour)

- 96417 (Chemotherapy administration, intravenous infusion technique; each additional sequential infusion)

- 96409 (Chemotherapy administration, intravenous, push technique, single or initial substance/drug)

- 96411 (Chemotherapy administration, intravenous, push technique, each additional substance/drug)

- 96423 (Chemotherapy administration, intra-arterial, infusion technique, up to 1 hour)

- 96450 (Chemotherapy administration, into CNS, spinal canal)

CPT code selection should be based on the specific services rendered and clinical documentation.

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