ICD Code E72.20

ICD code E72.20 is a diagnosis for a disorder of urea cycle metabolism that is not specified in detail.

1. Unexplained episodes of hyperammonemia

2. Symptoms of encephalopathy such as confusion, lethargy, or coma

3. History of vomiting, irritability, or poor feeding in infants

4. Laboratory evidence of elevated plasma ammonia levels

5. Absence of other identifiable causes for hyperammonemia

6. Abnormal plasma amino acid profile suggestive of urea cycle dysfunction

7. Family history of metabolic disorders or unexplained neonatal deaths

8. Failure to thrive or developmental delay without clear etiology

9. Neurological symptoms triggered by high-protein intake or catabolic stress

10. No specific enzyme deficiency identified after metabolic workup

Relevant CPT codes that may be used to treat ICD code E72.20 include:

- 36415: Collection of venous blood by venipuncture

- 80051: Electrolyte panel

- 82103: Ammonia, quantitative

- 82131: Amino acids, quantitative, each specimen

- 82947: Glucose; quantitative, blood (except reagent strip)

- 96365: Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour

- 99202–99215: Evaluation and management (E/M) services (office or other outpatient visits)

- 99406–99409: Behavioral counseling for risk factor reduction (if applicable)

- 96372: Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular

CPT code selection should be based on the specific services rendered and clinical scenario.

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