ICD Code D68.51

ICD code D68.51 is a classification used to identify and document the medical condition known as Activated Protein C Resistance. This condition is a genetic disorder that affects the blood's ability to clot properly, often leading to an increased risk of developing abnormal blood clots, such as deep vein thrombosis or pulmonary embolism. The code is used by healthcare providers to ensure accurate diagnosis, treatment planning, and billing for services related to this specific coagulation disorder.

1. Family History of Thrombophilia: Consider using the ICD code when there is a documented family history of thrombophilia, particularly if relatives have been diagnosed with conditions related to activated protein C resistance.

2. Recurrent Venous Thromboembolism (VTE): Use the ICD code for patients who have experienced multiple episodes of venous thromboembolism, such as deep vein thrombosis or pulmonary embolism, without an obvious cause.

3. Unprovoked Thrombosis: Apply the ICD code when a patient presents with thrombosis that occurs without any identifiable risk factors, such as surgery, trauma, or prolonged immobilization.

4. Thrombosis at a Young Age: Utilize the ICD code for patients who develop thrombotic events at a young age, typically under 50, which may suggest an underlying genetic predisposition.

5. Thrombosis in Unusual Sites: Consider the ICD code when thrombosis occurs in atypical locations, such as cerebral, mesenteric, or portal veins, which may indicate an underlying resistance to activated protein C.

6. Complications During Pregnancy: Use the ICD code for pregnant patients who experience complications such as recurrent miscarriages, preeclampsia, or placental abruption, which may be linked to activated protein C resistance.

7. Laboratory Confirmation: Apply the ICD code when laboratory tests confirm activated protein C resistance, typically through assays that measure the functional activity of protein C or genetic testing for factor V Leiden mutation.

8. History of Stroke or Myocardial Infarction: Consider using the ICD code for patients with a history of stroke or myocardial infarction, especially if these events occurred at a young age or without traditional risk factors.

9. Screening in High-Risk Populations: Use the ICD code when screening individuals in high-risk populations, such as those with a personal or family history of thrombotic disorders, to identify potential resistance to activated protein C.

For the ICD code D68.51, which pertains to activated protein C resistance, the relevant CPT codes that may be applicable for treatment or diagnostic procedures include:

1. 85610 - Prothrombin time; this test is often used to evaluate the extrinsic pathway of coagulation and can be relevant in assessing clotting disorders.

2. 85730 - Thromboplastin time, partial (PTT); this test evaluates the intrinsic pathway of coagulation and is useful in diagnosing bleeding disorders.

3. 85307 - Coagulation and fibrinolysis, functional activity of protein C; this test measures the activity of protein C, which is relevant for diagnosing resistance.

4. 85303 - Coagulation and fibrinolysis, protein C antigen; this test measures the level of protein C antigen in the blood.

5. 85306 - Coagulation and fibrinolysis, protein S antigen; although primarily related to protein S, it can be part of a comprehensive evaluation of coagulation disorders.

These CPT codes are used to bill for laboratory tests and procedures that help in diagnosing and managing conditions associated with activated protein C resistance. It is important for healthcare providers to select the appropriate CPT codes based on the specific services rendered and the clinical context.

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