ICD Code D84.821

ICD code D84.821 is immunodeficiency caused by the use of medications that weaken the immune system.

1. Patient has a documented immunodeficiency state.

2. Immunodeficiency is directly attributable to the use of prescribed or over-the-counter drugs.

3. There is clinical evidence of increased susceptibility to infections or impaired immune response.

4. No evidence of primary (congenital) immunodeficiency or immunodeficiency due to other causes such as HIV, malignancy, or systemic disease.

5. Symptoms may include recurrent infections, poor wound healing, or atypical infection presentations.

6. Drug history reveals recent or ongoing use of immunosuppressive agents, corticosteroids, chemotherapy, or other medications known to suppress immune function.

7. Laboratory findings may show decreased immunoglobulin levels, lymphopenia, or other markers of immune suppression consistent with drug effect.

Relevant CPT codes that may be used to treat ICD code D84.821 include:

- 96365: Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour

- 96366: Each additional hour (List separately in addition to code for primary procedure)

- 96372: Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular

- 96413: Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug

- 96415: Each additional hour (List separately in addition to code for primary procedure)

- 99211–99215: Office or other outpatient visit codes (for evaluation and management related to immunodeficiency management)

- 36415: Collection of venous blood by venipuncture

- 86580: Tuberculosis, intradermal test (if immunosuppression screening is required)

- 90772: Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular

CPT code selection should be based on the specific treatment or management provided for D84.821.

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