ICD Code I21-
ICD code I21- is used to classify and identify different types of acute myocardial infarction, commonly known as a heart attack.
Boost patient experience and your bottom line by automating patient cost estimates, payer underpayment detection, and contract optimization in one place.
What is ICD diagnosis code I21-
ICD code I21- is acute myocardial infarction, which refers to a heart attack caused by a sudden blockage of blood flow to the heart muscle.
When to use ICD code I21-
1. Presence of chest pain or discomfort suggestive of myocardial ischemia
2. Elevated cardiac biomarkers (e.g., troponin) indicating myocardial injury
3. Electrocardiogram (ECG) changes consistent with acute myocardial infarction (e.g., ST-segment elevation, new left bundle branch block, or pathological Q waves)
4. Symptoms onset within the past 28 days
5. Evidence of myocardial necrosis in a clinical setting consistent with acute coronary syndrome
6. Exclusion of non-ischemic causes of elevated cardiac biomarkers (e.g., myocarditis, trauma)
Billable CPT codes for ICD code I21-
Relevant CPT codes that may be used to treat ICD code I21- include:
92928, 92920, 92929, 92941, 92943, 93454, 93458, 93459, 93460, 93461, 92973, 92975, 92977, 92978, 92979, 92980, 92981, 92982, 92984, 92995, 92996, 93010, 93015, 93016, 93017, 93018, 99291, 99292
Are you being underpaid for encounters with I21-
See how MD Clarity’s RevFind software can read your payer contracts and automatically detect underpayments for CPT codes related to ICD code I21-. Schedule a demo today to ensure you’re capturing every dollar your organization has earned.
Get paid in full by bringing clarity to your revenue cycle
Related ICD Codes
Subscribe to the

Healthcare Clarified newsletter
Get the latest insights on RCM and healthcare policy in your inbox
