ICD Code Z16.12

ICD code Z16.12 is resistance to multiple antibiotics.

1. Laboratory-confirmed presence of infection caused by a bacterial organism

2. Evidence from culture or sensitivity testing indicating resistance to multiple antibiotics

3. Documentation that the bacteria are resistant specifically to multiple drugs, not just a single class of antibiotics

4. Clinical symptoms consistent with an active infection (e.g., fever, localized pain, inflammation, purulent discharge)

5. Provider documentation specifying multidrug-resistant bacterial infection as a complicating factor in patient management

Relevant CPT codes that may be used to treat ICD code Z16.12 include:

- 87086 (Urine culture, bacterial; quantitative, colony count)

- 87088 (Urine culture, bacterial; each isolate, with susceptibility studies)

- 87186 (Susceptibility studies, antimicrobial agent; microdilution or agar dilution)

- 87184 (Susceptibility studies, antimicrobial agent; disk method)

- 99201–99499 (Evaluation and management services, as appropriate for patient encounter)

- 96372 (Therapeutic, prophylactic, or diagnostic injection; subcutaneous or intramuscular)

- 96365 (Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hour)

CPT code selection should be based on the specific services rendered and clinical scenario associated with ICD code Z16.12.

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